Endocrine Abstracts

Aim: In chronic kidney disease (CKD) elevated aldosterone (Aldo) levels are a poor prognostic indicator, particularly in the context of a high dietary sodium intake, through unclear mechanisms. Blockade of the mineralocorticoid receptor (MR) improves surrogate patient outcomes. We hypothesised that regulation of aldosterone biosynthesis is disordered in CKD and aimed to compare this in a cohort of patients with CKD with subjects with essential hypertension (EH).<p class="a...

Background: Primary Aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Animal and in vitro studies have demonstrated that exposure to aldosterone and sodium leads to cardiac fibrosis and hypertrophy and this may, partly, be mediated by inflammation and oxidative stress. We aimed to clarify the effects of aldosterone excess on myocardial structure and composition in humans using contrast-enhanced cardiac MRI as well a...

Aim: Increasing left ventricular mass index (LVMI) is associated with a poor prognosis in patients with chronic kidney disease (CKD). Blockade of the mineralocorticoid receptor (MR) in CKD leads to improvement in proteinuria and LV mass. However, the MR can be activated by aldosterone, cortisol and deoxycorticosterone (DOC) and their relative contribution to adverse events in CKD is unclear. We aimed to assess the correlation between mineralocorticoid excretion and LVMI in pat...